{"id":396,"date":"2012-12-09T22:59:27","date_gmt":"2012-12-09T13:59:27","guid":{"rendered":"http:\/\/www.pharm.okayama-u.ac.jp\/lab\/meneki\/?page_id=396"},"modified":"2026-04-15T20:19:07","modified_gmt":"2026-04-15T11:19:07","slug":"dc","status":"publish","type":"page","link":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/research\/dc\/","title":{"rendered":"\u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u63d0\u793a"},"content":{"rendered":"

\u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u63d0\u793a<\/span><\/h2>\n

\u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u63d0\u793a<\/span><\/h3>\n

\u6a39\u72b6\u7d30\u80de\u306f\u3001\u751f\u4f53\u306b\u4fb5\u5165\u3057\u305f\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u75c5\u539f\u4f53\u3092\u53d6\u308a\u8fbc\u307f\u3001\u305d<\/span>\u308c\u3089\u3092\u514d\u75ab\u5fdc\u7b54\u306e\u53f8\u4ee4\u5854\u3067\u3042\u308bT<\/span>\u7d30\u80de\u3078\u3068\u63d0\u793a\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u7279\u7570\u7684\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3001\u307e\u305f\u751f\u4f53\u5185\u3067\u767a\u751f\u3057\u305f\u816b\u760d\u306b\u5bfe\u3057\u3066\u3082\u540c\u69d8\u306b\u3001\u816b\u760d\u7279\u7570\u7684\u6297\u539f\u3092\u6a39\u72b6\u7d30\u80de\u304c\u3000T<\/span>\u7d30\u80de\u3078\u63d0\u793a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u514d\u75ab\u5fdc\u7b54\u304c\u8a98\u5c0e\u3055\u308c\u3001\u751f\u4f53\u5185\u304b\u3089\u6392\u9664\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044<\/span>\u307e\u3059\u3002\u3053\u306e\u3001\u751f\u4f53\u306b\u3068\u3063\u3066\u306e\u7570\u7269\u3067\u3042\u308b\u6297\u539f\u3092T<\/span>\u7d30\u80de\u3068\u6297\u539f\u63d0\u793a\u3059\u308b\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\u5206\u5b50\u304c\u4e3b\u8981<\/span>\u7d44\u7e54\u9069\u5408\u6297\u539f\u30af\u30e9\u30b9II (MHC-II)<\/span>\u3067\u3059\u3002MHC-II<\/span>\u306f\u3001\u305d\u308c\u305e\u308c\u4e00\u56de\u819c\u8cab\u901a\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u03b1\u9396\u3068\u03b2<\/span>\u9396\u306e\u304b\u3089\u306a\u308b\u4e8c\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u5916\u6765\u306e\u6297\u539f\u30da\u30d7\u30c1\u30c9\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001\u305d<\/span>\u306e\u6297\u539f\u3092\u6297\u539f\u7279\u7570\u7684\u306aT<\/span>\u7d30\u80de\u3078\u3068\u63d0\u793a\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3061\u307e\u3059\u3002<\/span><\/span><\/p>\n

\"\"<\/a><\/p>\n

\u7d30\u80de\u5185\u8f38\u9001\u306b\u3088\u308b\u6297\u539fMHC-II<\/span>\u8907\u5408\u4f53\u306e\u5f62\u6210<\/span><\/h3>\n

MHC-II<\/span>\u306f\u7d30\u80de\u5185\u306e\u5c0f\u80de\u4f53\u3067\u7ffb\u8a33\u3055\u308c\u3001\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u8f38\u9001\u7d4c\u8def\u306b\u3088\u3063\u3066\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u9846\u7c92\u3067\u3042\u308bMHC-II<\/span>\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8(MIIC)<\/span>\u3078\u3068\u8f38\u9001\u3055\u308c\u305d\u3053\u3067\u6297\u539f\u3092\u7d50\u5408\u3057\u307e\u3059\u3002\u3053\u306e\u8f38\u9001\u904e\u7a0b\u3067MHC-II<\/span>\u304c\u7d30\u80de\u306e\u6301\u3064\u5185\u5728\u6027\u306e\u30da\u30d7\u30c1\u30c9\u3068\u7d50\u5408\u3057\u306a\u3044\u3088\u3046\u306b\u3001MHC-II<\/span>\u306e\u6297\u539f\u7d50\u5408\u90e8\u4f4d\u306f\u30a4\u30f3\u30d0\u30ea\u30a2\u30f3\u30c8\u9396(Ii)<\/span>\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u3063\u3066\u585e\u304c\u308c\u3066\u304a\u308a\u3001MIIC<\/span>\u307e\u3067\u8f38\u9001\u3055\u308c\u308b\u3068\u3001MHC-II<\/span>\u306b\u7d50\u5408\u3057\u305fIi<\/span>\u306f\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001\u6a39\u72b6\u7d30\u80de\u5185\u3078\u53d6\u308a\u8fbc\u307e\u308c\u305f\u75c5\u539f\u7d30\u83cc\u306a\u3069\u306e\u7570\u7269\u306f\u3001\u7d30\u80de<\/span>\u5185\u3067\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u30da\u30d7\u30c1\u30c9\u65ad\u7247\u3068\u306a\u308a\u3001MIIC<\/span>\u3078\u3068\u8f38\u9001\u3055\u308c\u3001\u305d\u3053\u3067MHC-II<\/span>\u3068\u7d50\u5408\u3057\u307e\u3059\u3002\u3053\u3046\u3057\u3066\u5f62\u6210\u3055\u308c\u305f\u6297\u539f-MHC-II<\/span>\u8907\u5408\u4f53\u306f\u3001MIIC<\/span>\u304b\u3089\u7d30\u80de\u8868\u9762\u3078\u3068\u8f38\u9001\u3055\u308c\u307e\u3059\u3002\u7d30\u80de\u8868\u9762\u306b\u767a\u73fe\u3057\u305fMHC-II<\/span>\u306f\u7d30\u80de\u5185\u3078\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5f8c\u3001\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3078\u3068\u8f38\u9001\u3055\u308c\u307e\u3059\u304c\u3001\u4e00\u90e8\u306f\u30ea\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u7d4c\u8def\u306b\u3088\u308a\u518d\u3073\u7d30\u80de\u8868\u9762\u3078\u8f38\u9001\u3055\u308c\u3001\u4e00\u90e8\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u3078\u3068\u8f38\u9001\u3055\u308c\u5206\u89e3\u3055\u308c\u307e\u3059\u3002<\/span><\/span><\/p>\n

\"\"<\/a><\/span><\/p>\n

 <\/p>\n

\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308bMHC-II<\/span>\u306e\u7d30\u80de\u8868\u9762\u767a\u73fe\u8abf\u7bc0<\/span><\/h3>\n

\u3053\u306e\u3088\u3046\u306a\u6a5f\u69cb\u3067\u7d30\u80de\u8868\u9762\u306e\u6297\u539fMHC-II<\/span>\u8907\u5408\u4f53\u306f\u5f62\u6210\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u767a\u73fe\u91cf\u306e\u8abf\u7bc0\u306f\u3001\u9069\u5207\u306a\u514d\u75ab\u5fdc\u7b54\u306b\u91cd\u8981\u3067\u3059\u3002\u6a39\u72b6\u7d30\u80de\u306f\u3001Toll<\/span>\u69d8\u53d7\u5bb9\u4f53(TLR)<\/span>\u3067\u75c5\u539f\u4f53\u7531\u6765\u7269\u8cea\u3092\u611f\u77e5\u3059\u308b\u3068\u3001\u7d30\u80de\u8868\u9762\u306eMHC<\/span>\u767a\u73fe\u91cf\u304c\u4e0a\u6607\u3057\u75c5\u539f\u4f53\u7531\u6765\u30da\u30d7\u30c1\u30c9\u3092\u52b9\u7387\u3088\u304fT<\/span>\u7d30\u80de\u306b\u63d0\u793a\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u8fd1\u5e74\u3001\u3053\u306eMHC-II<\/span>\u306e\u7d30\u80de\u8868\u9762\u767a\u73fe\u306fMHC-II<\/span>\u81ea\u8eab\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u3055\u308c\u307e\u3057\u305f\u3002\u75c5\u539f\u4f53\u306e\u523a\u6fc0\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u672a\u6210\u719f\u6a39\u72b6\u7d30\u80de\u3067\u306f\u3001MHC-II<\/span>\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u3066\u304a\u308a\u3001MHC-II<\/span>\u306f\u4f4e\u767a\u73fe\u3067\u3059\u304c\u3001\u75c5\u539f\u4f53\u306e\u523a\u6fc0\u3092\u53d7\u3051\u305f\u6a39\u72b6\u7d30\u80de\u3067\u306fMHC-II<\/span>\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306f\u6d88\u5931\u3057\u3001MHC-II<\/span>\u306f\u9ad8\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306fEGF<\/span>\u53d7\u5bb9\u4f53\u306a\u3069\u306e\u7d30\u80de\u8868\u9762\u3078\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001MHC-II<\/span>\u306b\u3064\u3044\u3066\u3082\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304c\u7d30\u80de\u8868\u9762\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u53e4\u7530\u51c6\u6559\u6388\u3089\u306fMHC-II<\/span>\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20\u306e\u3072\u3068\u3064\u3067\u3042\u308bMARCH-I<\/span>\u306b\u7740\u76ee\u3057\u3001\u672a\u6210\u719f\u6a39\u72b6\u7d30\u80de\u304a\u3088\u3073\u6210\u719f\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3051\u308bMARCH-I<\/span>\u306e\u767a\u73fe\u91cf\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001\u69d8\u3005\u306aTRL<\/span>\u30ea\u30ac\u30f3\u30c9\u3067\u523a\u6fc0\u3057\u305f\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3044\u3066\u3001MARCH-I<\/span>\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002<\/span>\u3053\u306e\u7d50<\/span>\u679c\u306f\u3001MARCH-I<\/span>\u306b\u3088\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304cMHC-II<\/span>\u306e\u767a\u73fe\u3092\u898f\u5b9a\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059(J Biol Chem<\/em>, 2010)<\/span>\u3002\u3055\u3089\u306b\u53e4\u7530\u51c6\u6559\u6388\u3089\u306f\u3001\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3044\u3066MARCH-I<\/span>\u304c<\/span>\u5b9f\u969b\u306bMHC-II<\/span>\u3092\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u3068\u3057\u307e\u3057\u305f\u3002\u307e\u305fMHC-II<\/span>\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304c\u3069\u306e\u3088\u3046\u306b<\/span>MHC-II<\/span>\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u306e\u304b\u3092\u89e3\u6790\u3057\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306fMHC-II<\/span>\u3092\u5206\u89e3\u3078\u3068\u8a98\u5c0e\u3059\u308b\u70ba\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u3068\u3057\u307e\u3057\u305f(Proc Natl Acad Sci USA<\/em>, 2010)<\/span>\u3002<\/span><\/span><\/p>\n

\"\"<\/a><\/p>\n

(1) Walseng E, Furuta K<\/span>, Goldszmid RS, Weih KA, Sher A, Roche PA:\u00a0Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. J Biol Chem.<\/em><\/strong>\u00a0 285(53):41749-54. (2010)<\/p>\n

(2)\u00a0Furuta K<\/span>, Ishido S, Roche PA:\u00a0Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells. Proc Natl Acad Sci U S A.<\/strong><\/em>\u00a0109(47):19380-5. (2012)<\/p>\n

 <\/p>\n

\u7d30\u80de\u5185\u8f38\u9001\u306b\u3088\u308bMHC-II<\/span><\/span>\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u5236\u5fa1<\/span><\/span><\/h3>\n

\u6297\u539fMHC-II<\/span>\u8907\u5408\u4f53\u306e\u5f62\u6210\u904e\u7a0b\u306b\u304a\u3044\u3066\u306f\u3001MHC-II<\/span>\u306f\u3001\u307e\u305a\u5c0f\u80de\u4f53\u5185\u3067\u30a4\u30f3\u30d0\u30ea\u30a2\u30f3\u30c8\u9396\u3092\u7d50\u5408\u3057\u305f\u524d\u99c6\u4f53(Ii-MHC-II)<\/span>\u304c\u5f62\u6210\u3055\u308c\u3001\u4e00\u65e6\u7d30\u80de\u8868\u9762\u306b\u8f38\u9001\u3055\u308c\u305f\u5f8cMIIC<\/span>\u307e\u3067\u8f38\u9001\u3055\u308c\u3001\u305d\u3053\u3067\u6297\u539f\u3092\u7d50\u5408\u3057\u3001\u6297\u539fMHC-II<\/span>\u8907\u5408\u4f53(pMHC-II)<\/span>\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u306epMHC-II<\/span>\u306f\u7d30\u80de\u8868\u9762\u3078\u3068\u8f38\u9001\u3055\u308c\u3001\u305d\u3053\u3067\u6297\u539f\u3092T<\/span>\u7d30\u80de\u3078\u3068\u63d0\u793a\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306bIi-MHC-II<\/span>\u3001pMHC-II<\/span>\u306f\u5171\u306b\u7d30\u80de\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u306b\u3082\u95a2\u308f\u3089\u305apMHC-II<\/span>\u306f\u5f79\u5272\u3092\u7d42\u3048\u308b\u3068\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u3001\u901f\u3084\u304b\u306b\u5206\u89e3\u3055\u308c\u308b\u4e00\u65b9\u3001Ii-MHC-II<\/span>\u306f\u5206\u89e3\u3055\u308c\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u9078\u629e\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002\u53e4\u7530\u51c6\u6559\u6388\u3089\u306e\u6700\u8fd1\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u3053\u306e\u9055\u3044\u306fMHC-II<\/span>\u304c\u7d30\u80de\u8868\u9762\u304b\u3089\u7d30\u80de\u5185\u3078\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3055\u308c\u308b\u7d4c\u8def\u306e\u9055\u3044\u306b\u3088\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001MHC-II<\/span>\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316<\/span>\u9175\u7d20\u3067\u3042\u308bMARCH-I<\/span>\u306f\u7279\u5b9a\u306e\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306b\u5c40\u5728\u3057\u3001pMHC-II<\/span>\u306f\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5f8c\u3053\u306e\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3067\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u3001\u5206\u89e3\u7d4c\u8def\u3078\u3068\u8f38\u9001\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u6642pMHC-II<\/span>\u306f\u30af\u30e9\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u306b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001Ii-MHC-II<\/span>\u306f\u7d30\u80de\u8868\u9762\u304b\u3089\u30af\u30e9\u30b9\u30ea\u30f3\u4f9d\u5b58\u7684\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7<\/span>\u30b9\u306b\u3088\u3063\u3066\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306b\u8f38\u9001\u3055\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306b\u306fMARCH-I<\/span>\u304c\u5c40\u5728\u3057\u3066<\/span>\u304a\u3089\u305a\u3001Ii-MHC-II<\/span>\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u306a\u3044\u305f\u3081\u3001\u5206\u89e3\u3092\u514d\u308cMIIC<\/span>\u3078\u3068\u8f38\u9001\u3055\u308c\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u524d<\/span>\u99c6\u4f53MHC-II<\/span>\u306f\u6297\u539f\u3092\u7d50\u5408\u3057\u305fMHC-II<\/span>\u3068\u306f\u7570\u306a\u308b\u7d4c\u8def\u3067\u7d30\u80de\u5185\u3092\u8f38\u9001\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u5206\u89e3\u3092\u56de\u907f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f(Proc Natl Acad Sci USA<\/em>, 2013)\u3002<\/span><\/span><\/span><\/p>\n

(1)\u00a0Furuta K<\/span>, Walseng E, Roche PA:\u00a0Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation.\u00a0Proc Natl Acad Sci U S A.\u00a0<\/em><\/strong>110(50):20188-93. (2013)<\/p>\n

 <\/p>\n

\u6d3b\u6027\u5316T<\/span>\u7d30\u80de\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u8868\u9762MHC-II<\/span><\/span>\u306e\u767a\u73fe\u6291\u5236<\/span><\/span><\/h3>\n

\u6a39\u72b6\u7d30\u80de\u306fMHC-II<\/span>\u306b\u3088\u308b\u6297\u539f\u63d0\u793a\u306b\u3088\u3063\u3066\u3001\u30ca\u30a4\u30fc\u30d6CD<\/span><\/span>4<\/span>\u967d\u6027T<\/span>\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u53e4\u7530\u51c6\u6559\u6388\u306f\u3001\u6d3b\u6027\u5316\u3055\u308c\u305fT<\/span>\u7d30\u80de\u306f\u6a39\u72b6\u7d30\u80de\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u30ca\u30a4\u30fc\u30d6T<\/span>\u7d30\u80de\u6d3b\u6027\u5316\u80fd\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u3092\u884c\u306a\u3044\u3001\u6d3b\u6027\u5316T<\/span>\u7d30\u80de\u306e\u767a\u73fe\u3059\u308bT<\/span>\u7d30\u80de\u53d7\u5bb9\u4f53TCR<\/span>\u3068MHC-II<\/span>\u306e\u76f8\u4e92\u4f5c\u7528\u306fMHC-II<\/span>\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u4fc3\u9032\u3057\u3001\u7d30\u80de\u8868\u9762MHC-II<\/span>\u306e\u767a\u73fe\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6a39\u72b6\u7d30\u80de\u306e\u6297\u539f\u63d0\u793a\u80fd\u304c\u4f4e\u4e0b\u3057\u3001T<\/span>\u7d30\u80de\u306e\u6d3b\u6027\u5316\u304c\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u6a39\u72b6\u7d30\u80de\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u6a5f\u69cb\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059(Proc Natl Acad Sci USA<\/em>, 2012)\u3002<\/span><\/span><\/span><\/p>\n

\"\"<\/p>\n

(1)\u00a0Furuta K<\/span>, Ishido S, Roche PA:\u00a0Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells. Proc Natl Acad Sci U S A.<\/strong><\/em>\u00a0109(47):19380-5. (2012)<\/p>\n

(2)\u00a0Roche PA, Furuta K<\/span>:\u00a0The ins and outs of MHC class II-mediated antigen processing and presentation. Nat Rev Immunol.<\/em> <\/strong>15(4):203-16. (2015)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u63d0\u793a \u6a39\u72b6\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u63d0\u793a \u6a39\u72b6\u7d30\u80de\u306f\u3001\u751f\u4f53\u306b\u4fb5\u5165\u3057\u305f\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u75c5\u539f\u4f53\u3092\u53d6\u308a\u8fbc\u307f\u3001\u305d\u308c\u3089\u3092\u514d\u75ab\u5fdc\u7b54\u306e\u53f8\u4ee4\u5854\u3067\u3042\u308bT\u7d30\u80de\u3078\u3068\u63d0\u793a\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u7279\u7570\u7684\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3001\u307e\u305f\u751f […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":25,"menu_order":2,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/396"}],"collection":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/comments?post=396"}],"version-history":[{"count":24,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/396\/revisions"}],"predecessor-version":[{"id":1684,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/396\/revisions\/1684"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/25"}],"wp:attachment":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/media?parent=396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

\"\"<\/a><\/p>\n