{"id":924,"date":"2019-03-16T17:55:29","date_gmt":"2019-03-16T08:55:29","guid":{"rendered":"http:\/\/www.pharm.okayama-u.ac.jp\/lab\/meneki\/?page_id=924"},"modified":"2022-09-15T20:52:28","modified_gmt":"2022-09-15T11:52:28","slug":"atarashii","status":"publish","type":"page","link":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/research\/atarashii\/","title":{"rendered":"\u65b0\u3057\u3044\u8a55\u4fa1\u7cfb\u3092\u5229\u7528\u3057\u305f\u7d30\u83cc\u306e\u75c5\u539f\u6027\u30b7\u30b9\u30c6\u30e0\u306e\u89e3\u660e"},"content":{"rendered":"

\u65b0\u3057\u3044\u8a55\u4fa1\u7cfb\u3092\u5229\u7528\u3057\u305f\u7d30\u83cc\u306e\u75c5\u539f\u6027\u30b7\u30b9\u30c6\u30e0\u306e\u89e3\u660e<\/span><\/h2>\n

\u30ab\u30a4\u30b3\u611f\u67d3\u30e2\u30c7\u30eb\u306e\u69cb\u7bc9\u3068\u7d30\u83cc\u306e\u75c5\u539f\u6027\u907a\u4f1d\u5b50\u306e\u63a2\u7d22<\/span><\/h3>\n

\u7d30\u83cc\u304c\u52d5\u7269\u3092\u6b7b\u306b\u81f3\u3089\u3057\u3081\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u52d5\u7269\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u767a\u73fe\u306b\u95a2\u308f\u308b\u7d30\u83cc\u56e0\u5b50\u7fa4\u3092\u591a\u6570\u540c\u5b9a\u3057\u3001\u305d\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u611f\u67d3\u30e2\u30c7\u30eb\u52d5\u7269\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u30de\u30a6\u30b9\u306a\u3069\u306e\u307b\u4e73\u52d5\u7269\u306f\u502b\u7406\u7684\u306a\u89b3\u70b9\u3068\u30b3\u30b9\u30c8\u9762\u304b\u3089\u591a\u6570\u306e\u500b\u4f53\u6570\u3092\u6271\u3046\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001\u75c5\u539f\u6027\u56e0\u5b50\u306e\u7db2\u7f85\u7684\u540c\u5b9a\u306b\u306f\u9069\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u7dda\u866b\u3084\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306a\u3069\u306e\u7121\u810a\u690e\u30e2\u30c7\u30eb\u52d5\u7269\u306f\u4f53\u306e\u5927\u304d\u3055\u304c\u5c0f\u3055\u304f\u3001\u5b9a\u91cf\u7684\u306a\u30b5\u30f3\u30d7\u30eb\u306e\u6ce8\u5c04\u306b\u3088\u308b\u611f\u67d3\u5b9f\u9a13\u304c\u56f0\u96e3\u3067\u3059\u3002\u57a3\u5185\u3089\u306f\u3001\u3053\u306e\u554f\u984c\u70b9\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306b\u3001\u6606\u866b\u3067\u3042\u308b\u30ab\u30a4\u30b3\u3092\u5229\u7528\u3057\u305f\u611f\u67d3\u30e2\u30c7\u30eb\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u30d2\u30c8\u306b\u611f\u67d3\u3059\u308b\u75c5\u539f\u6027\u7d30\u83cc\u306f\u30ab\u30a4\u30b3\u306b\u5bfe\u3057\u3066\u81f4\u6b7b\u6027\u3092\u793a\u3057\u3001\u975e\u75c5\u539f\u6027\u7d30\u83cc\u306f\u81f4\u6b7b\u6027\u3092\u793a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30ab\u30a4\u30b3\u611f\u67d3\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u7d30\u83cc\u306e\u75c5\u539f\u6027\u56e0\u5b50\u306e\u540c\u5b9a\u3092\u8a66\u307f\u308b\u305f\u3081\u3001\u30d2\u30c8\u306b\u611f\u67d3\u3059\u308b\u75c5\u539f\u6027\u7d30\u83cc\u3067\u3042\u308b\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6a5f\u80fd\u672a\u77e5\u907a\u4f1d\u5b50\u7fa4\u306e\u7834\u58ca\u682a\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u4f5c\u51fa\u3057\u3001\u30ab\u30a4\u30b3\u6bba\u50b7\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u682a\u3092\u63a2\u7d22\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001RNA\u306e\u4fee\u98fe\u9175\u7d20\u3001RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u4ee3\u8b1d\u9175\u7d20\u306a\u3069\u3001\u3053\u308c\u307e\u3067\u75c5\u539f\u6027\u3078\u306e\u95a2\u4e0e\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u306a\u3044\u7d30\u83cc\u56e0\u5b50\u7fa4\u306e\u6b20\u640d\u304c\u30ab\u30a4\u30b3\u306b\u5bfe\u3059\u308b\u6bba\u50b7\u80fd\u529b\u306e\u4f4e\u4e0b\u3092\u5c0e\u304f\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u56e0\u5b50\u306f\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u306b\u3082\u5fc5\u8981\u3067\u3057\u305f\u3002\u30ab\u30a4\u30b3\u611f\u67d3\u30e2\u30c7\u30eb\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u65b0\u898f\u75c5\u539f\u6027\u56e0\u5b50\u306e\u7db2\u7f85\u7684\u540c\u5b9a\u3068\u305d\u308c\u3089\u304c\u62c5\u3046\u75c5\u539f\u6027\u767a\u73fe\u6a5f\u69cb\u306e\u89e3\u660e\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n

\"\"<\/p>\n

(1) Kaito C<\/u>, Akimitsu N, Watanabe H, Sekimizu K: Silkworm larvae as an animal model of bacterial infection pathogenic to humans. Microbial Pathogenesis<\/em><\/strong> 32:183-90 (2002)<\/span><\/p>\n

(2) Kaito C<\/u>, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K: Silkworm-pathogenic bacteria infection model for identification of novel virulence genes. Mol Microbiol.<\/em><\/strong> 56:934-44 (2005)<\/span><\/p>\n

(3) Kaito C<\/u>, Morishita D, Matsumoto Y, Kurokawa K, Sekimizu K: Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus<\/em>. Mol Microbiol.<\/em><\/strong> 62:1601-1617. (2006)<\/span><\/p>\n

(4) Numata S, Nagata M, Mao H, Sekimizu K, Kaito C<\/u>: CvfA protein and PNPase act in an opposing manner to regulate Staphylococcus aureus<\/em> virulence. J Biol Chem.<\/em><\/strong> 289(12):8420-31. (2014)<\/span><\/p>\n

(5) Kyuma T, Kimura S, Hanada Y, Suzuki T, Sekimizu K, Kaito C<\/u>: Ribosomal RNA methyltransferases contribute to Staphylococcus aureus<\/em> virulence. The FEBS Journal<\/em><\/strong> 282(13):2570-84. (2015)<\/span><\/p>\n

(6) Imae K, Saito Y, Kizaki H, Ryuno H, Mao H, Miyashita A, Suzuki Y, Sekimizu K, Kaito C<\/u>: Novel nucleoside diphosphatase contributes to Staphylococcus aureus <\/em>virulence. J Biol Chem.<\/em><\/strong> 291(36):18608-19. (2016) \u201cPaper of the Week\u201d<\/span><\/p>\n

 <\/p>\n

\u7d30\u83cc\u306e\u75c5\u539f\u6027\u3092\u6291\u5236\u3059\u308b\u751f\u4f53\u9632\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<\/span><\/h3>\n

\u30ab\u30a4\u30b3\u611f\u67d3\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u75c5\u539f\u6027\u907a\u4f1d\u5b50\u306e\u7279\u5fb4\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u904e\u7a0b\u3067\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u306f\u30ab\u30a4\u30b3\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u306b\u5fc5\u8981\u3067\u306a\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u7cbe\u88fd\u3057\u305f\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u3092\u30ab\u30a4\u30b3\u306b\u6ce8\u5c04\u3059\u308b\u3068\u3001\u30ab\u30a4\u30b3\u306f\u6b7b\u4ea1\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u57a3\u5185\u3089\u306f\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u767a\u73fe\u304c\u30ab\u30a4\u30b3\u4f53\u5185\u3067\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3068\u4eee\u8aac\u3092\u305f\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30ab\u30a4\u30b3\u4f53\u6db2\u4e2d\u306e\u8102\u8cea\u8f38\u9001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u5897\u6b96\u306b\u306f\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306a\u304f\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30ab\u30a4\u30b3\u306e\u8102\u8cea\u8f38\u9001\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u83cc\u4f53\u8868\u5c64\u306e\u591a\u7cd6\u985e\u3067\u3042\u308b\u30ea\u30dd\u30bf\u30a4\u30b3\u9178\u306b\u7d50\u5408\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30ab\u30a4\u30b3\u306e\u8102\u8cea\u8f38\u9001\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f8\u540c\u6027\u3092\u6709\u3059\u308b\u54fa\u4e73\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u6bd2\u7d20\u767a\u73fe\u3092\u6291\u5236\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u306f\u3001\u7d30\u83cc\u3092\u6bba\u3055\u305a\u306b\u3001\u7d30\u83cc\u306e\u75c5\u539f\u6027\u3092\u6291\u5236\u3059\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u751f\u4f53\u9632\u5fa1\u6a5f\u69cb\u304c\u6606\u866b\u3068\u54fa\u4e73\u985e\u306e\u9593\u3067\u5171\u901a\u3057\u3066\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\"\"<\/p>\n

(1) Hanada Y, Sekimizu K, Kaito C<\/u>: Silkworm apolipophorin protein inhibits Staphylococcus aureus <\/em>virulence. J Biol Chem.<\/em><\/strong> 286(45):39360-9. (2011)<\/span><\/p>\n

(2) Omae Y, Hanada Y, Sekimizu K, Kaito C<\/u>: Silkworm apolipophorin protein inhibits hemolysin gene expression of Staphylococcus aureus via<\/em> binding to cell surface lipoteichoic acids. J Biol Chem.<\/em><\/strong> 288(35):25542-50. (2013)<\/span><\/p>\n

 <\/p>\n

MRSA\u306e\u75c5\u539f\u6027\u6c7a\u5b9a\u6a5f\u69cb\u306e\u89e3\u660e<\/span><\/h3>\n

\u7d30\u83cc\u306e\u79fb\u52d5\u80fd\u529b\u306f\u305d\u306e\u75c5\u539f\u6027\u767a\u73fe\u306b\u91cd\u8981\u3067\u3059\u304c\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306f\u97ad\u6bdb\u3092\u6301\u305f\u306a\u3044\u305f\u3081\u306b\u79fb\u52d5\u80fd\u529b\u3092\u6301\u305f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u3092\u8edf\u5bd2\u5929\u57f9\u5730\u8868\u9762\u306b\u5857\u5e03\u3059\u308b\u3068\u3001\u5de8\u5927\u30b3\u30ed\u30cb\u30fc\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u57a3\u5185\u3089\u306f\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u3068\u547d\u540d\u3057\u305f\u3053\u306e\u73fe\u8c61\u304c\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u75c5\u539f\u6027\u8a55\u4fa1\u306b\u6709\u52b9\u306a\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001\u6b27\u7c73\u8af8\u56fd\u3092\u4e2d\u5fc3\u306b\u554f\u984c\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u30e1\u30c1\u30b7\u30ea\u30f3\u8010\u6027\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\uff08MRSA\uff09\u306e\u9ad8\u75c5\u539f\u6027\u682a\u3068MRSA\u306e\u4f4e\u75c5\u539f\u6027\u682a\u306e\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u80fd\u529b\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u9ad8\u75c5\u539f\u6027\u306eMRSA\u682a\u306f\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u80fd\u529b\u304c\u9ad8\u304f\u3001\u4f4e\u75c5\u539f\u6027\u306eMRSA\u682a\u306f\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u80fd\u529b\u304c\u4f4e\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u80fd\u529b\u306e\u9055\u3044\u3092\u5c0e\u304f\u907a\u4f1d\u5b50\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u306f\u4f4e\u75c5\u539f\u6027\u306eMRSA\u306b\u7279\u7570\u7684\u306b\u5b58\u5728\u3059\u308b\u907a\u4f1d\u5b50 psm-mec<\/em> \u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002psm-mec <\/em>\u907a\u4f1d\u5b50\u3092\u9ad8\u75c5\u539f\u6027\u306eMRSA\u682a\u306b\u5c0e\u5165\u3059\u308b\u3068\u3001\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u304c\u6291\u5236\u3055\u308c\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u6bd2\u7d20\u7523\u751f\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u304c\u6e1b\u5f31\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u65e5\u672c\u56fd\u5185\u306e\u75c5\u9662\u304b\u3089325\u682a\u306eMRSA\u3092\u53ce\u96c6\u3057\u3001psm-mec <\/em>\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068\u75c5\u539f\u6027\u3068\u306e\u95a2\u4fc2\u6027\u3092\u691c\u8a0e\u3057\u305f\u7d50\u679c\u3001\u7d043\u5272\u306eMRSA\u682a\u306b\u304a\u3044\u3066\u3001psm-mec <\/em>\u907a\u4f1d\u5b50\u304c\u5909\u7570\u3001\u307e\u305f\u306f\u6b20\u640d\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u6bd2\u7d20\u7523\u751f\u91cf\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u306f\u3001\u30b3\u30ed\u30cb\u30fc\u30b9\u30d7\u30ec\u30c3\u30c7\u30a3\u30f3\u30b0\u304cMRSA\u306e\u75c5\u539f\u6027\u8a55\u4fa1\u306e\u6307\u6a19\u3068\u306a\u308b\u3053\u3068\u3001\u306a\u3089\u3073\u306b\u3001psm-mec <\/em>\u907a\u4f1d\u5b50\u304cMRSA\u306e\u75c5\u539f\u6027\u306e\u6c7a\u5b9a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001psm-mec <\/em>\u907a\u4f1d\u5b50\u306b\u3088\u308b\u75c5\u539f\u6027\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u8a66\u307f\u305f\u7d50\u679c\u3001psm-mec <\/em>\u306e\u8ee2\u5199\u7523\u7269\u304c\u6a5f\u80fd\u6027RNA\u3068\u3057\u3066\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u75c5\u539f\u6027\u5236\u5fa1\u56e0\u5b50\u306e\u7ffb\u8a33\u3092\u963b\u5bb3\u3057\u3001\u75c5\u539f\u6027\u5236\u5fa1\u6a5f\u80fd\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u672c\u77e5\u898b\u306f\u3001\u7d30\u83cc\u304c\u6a5f\u80fd\u6027RNA\u306b\u3088\u308a\u81ea\u8eab\u306e\u75c5\u539f\u6027\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u7d30\u83cc\u306e\u75c5\u539f\u6027\u5236\u5fa1\u6a5f\u69cb\u306e\u7406\u89e3\u306b\u8ca2\u732e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n

\"\"<\/p>\n

(1) Kaito C<\/u>, Sekimizu K: Colony Spreading in Staphylococcus aureus<\/em>. J Bacteriol. <\/em><\/strong>189, 2553-7. (2007)<\/span><\/p>\n

(2) Kaito C<\/u>, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K: A novel gene, fudoh<\/em>, in the SCCmec<\/em> region suppresses the colony spreading ability and virulence in Staphylococcus aureus<\/em>. PLoS ONE<\/em><\/strong> 3:e3921. (2008)<\/span><\/p>\n

(3) Kaito C<\/u>, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K: Transcription and translation products of the cytolysin gene psm-mec<\/em> on the mobile genetic element SCCmec<\/em> regulate Staphylococcus aureus<\/em> virulence. PLoS Pathog<\/em><\/strong>. 7(2):e1001267. (2011)<\/span><\/p>\n

(4) Kaito C<\/u>, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, Sekimizu K: Mobile genetic element SCCmec<\/em>-encoded psm-mec <\/em>RNA suppresses translation of agrA <\/em>and attenuates MRSA virulence. PLoS Pathog.<\/em><\/strong> 9(4):e1003269. (2013)<\/span><\/p>\n

(5) Ikuo M, Nagano G, Saito Y, Mao H, Sekimizu K, Kaito C<\/u>: Inhibition of exotoxin production by mobile genetic element SCCmec<\/em>-encoded psm-mec <\/em>RNA is conserved in staphylococcal species. PLoS ONE<\/em><\/strong> 9(6):e100260. (2014)<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u65b0\u3057\u3044\u8a55\u4fa1\u7cfb\u3092\u5229\u7528\u3057\u305f\u7d30\u83cc\u306e\u75c5\u539f\u6027\u30b7\u30b9\u30c6\u30e0\u306e\u89e3\u660e \u30ab\u30a4\u30b3\u611f\u67d3\u30e2\u30c7\u30eb\u306e\u69cb\u7bc9\u3068\u7d30\u83cc\u306e\u75c5\u539f\u6027\u907a\u4f1d\u5b50\u306e\u63a2\u7d22 \u7d30\u83cc\u304c\u52d5\u7269\u3092\u6b7b\u306b\u81f3\u3089\u3057\u3081\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u52d5\u7269\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u767a\u73fe\u306b\u95a2\u308f\u308b\u7d30\u83cc\u56e0\u5b50\u7fa4\u3092\u591a\u6570\u540c\u5b9a\u3057\u3001\u305d\u306e\u6a5f\u80fd\u3092\u660e […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":25,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/924"}],"collection":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/comments?post=924"}],"version-history":[{"count":17,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/924\/revisions"}],"predecessor-version":[{"id":1705,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/924\/revisions\/1705"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/pages\/25"}],"wp:attachment":[{"href":"https:\/\/www.pharm.okayama-u.ac.jp\/lab\/bunsei\/wp-json\/wp\/v2\/media?parent=924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}