原著論文 (~2018)

(1) Mitsutomi S, Sekimizu K, *Kaito C
Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil.
Drug Discoveries and Therapeutics 11(5):267-275. (2017)

(2) Kochi Y, Matsumoto Y, Sekimizu K, *Kaito C
Two-spotted cricket as an animal infection model of human pathogenic fungi.
Drug Discoveries and Therapeutics 11(5):259-266. (2017)

(3) Kizaki H, Omae Y, Tabuchi F, Saito Y, Sekimizu K, *Kaito C
Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.
PLoS ONE. 11(10):e0164523. (2016)

(4) Imae K, Saito Y, Kizaki H, Ryuno H, Mao H, Miyashita A, Suzuki Y, Sekimizu K, *Kaito C
Novel nucleoside diphosphatase contributes to Staphylococcus aureus virulence.
J Biol Chem. 291(36):18608-19. (2016) “Paper of the Week”

(5) Kochi Y, Miyashita A, Tsuchiya K, Mitsuyama M, Sekimizu K, *Kaito C
A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.
FEMS Microbiology Lett. 363 (15): fnw163. (2016)

(6) Miyashita A, Kizaki H, Sekimizu K, *Kaito C
Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.
Biology Open 5(6):770-6. (2016)

(7) *Suzuki T, Yamamoto T, Kaito C, Miyamoto H, Ohashi Y
Impact of psm-mec in Methicillin-Resistant Staphylococcus aureus (ST764) Strains Isolated from Keratitis Patients.
Microb Drug Resist. 22(7):589-597. (2016)

(8) Miyashita A, Kizaki H, Sekimizu K, *Kaito C
No effect of body size on the frequency of calling and courtship song in the two-spotted cricket, Gryllus bimaculatus.
PLoS ONE 11(1): e0146999. (2016)

(9) Yoshikai H, Kizaki H, Saito Y, Omae Y, Sekimizu K, *Kaito C
Multidrug-resistance transporter AbcA secretes Staphylococcus aureus cytolytic toxins.
The Journal of Infectious Diseases 213(2):295-304. (2016)

(10) Kyuma T, Kizaki H, Ryuno H, Sekimizu K, *Kaito C
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.
Biochimie 119:166-74. (2015)

(11) Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, *Sekimizu K
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.
Sci Rep. 5:17092. (2015)

(12) Miyashita A, Takahashi S, Ishii K, Sekimizu K, *Kaito C
Primed immune responses triggered by ingested bacteria lead to systemic infection tolerance in silkworms.
PLoS ONE 10(6):e0130486. (2015)

(13) Kyuma T, Kimura S, Hanada Y, Suzuki T, Sekimizu K, *Kaito C
Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.
The FEBS Journal 282(13):2570-84. (2015)

(14) Miyashita A, Hirai Y, Sekimizu K, *Kaito C
Antibiotic-producing bacteria from stag beetle mycangia.
Drug Discoveries and Therapeutics 9(1):33-7. (2015)

(15) Ikuo M, Nagano G, Saito Y, Mao H, Sekimizu K, *Kaito C
Inhibition of exotoxin production by mobile genetic element SCCmec-encoded psm-mec RNA is conserved in staphylococcal species.
PLoS ONE 9(6):e100260. (2014)

(16) Omae Y, Sekimizu K, *Kaito C
Identification of Staphylococcus aureus Colony-Spreading Stimulatory Factors from Mammalian Serum.
PLoS ONE 9(5):e97670. (2014)

(17) Miyashita A, Kizaki H, Kawasaki K, Sekimizu K, *Kaito C
Primed immune responses to Gram-negative peptidoglycans confer infection resistance in silkworms.
J Biol Chem. 289(20):14412-14421. (2014)

(18) Numata S, Nagata M, Mao H, Sekimizu K, *Kaito C
CvfA protein and PNPase act in an opposing manner to regulate Staphylococcus aureus virulence.
J Biol Chem. 289(12):8420-31. (2014)

(19) *Aoyagi T^‡, Kaito C^‡ (^‡equally contribution), Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Kanamori H, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
Impact of psm-mec in the Mobile Genetic Element on the Clinical Characteristics and Outcome of SCCmec-II Methicillin-resistant Staphylococcus aureus Bacteremia in Japan.
Clin Microbiol Infect. 20(9):912-9. (2014)

(20) Omae Y, Hanada Y, Sekimizu K, *Kaito C
Silkworm apolipophorin protein inhibits hemolysin gene expression of Staphylococcus aureus via binding to cell surface lipoteichoic acids.
J Biol Chem. 288(35):25542-50. (2013)

(21) *Kaito C, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, Sekimizu K
Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence.
PLoS Pathog. 9(4):e1003269. (2013)

(22) Omae Y, Sekimizu K, *Kaito C
Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of delta-hemolysin.
J Biol Chem. 287(19):15570-9. (2012)

(23) Miyazaki S, Matsumoto Y, Sekimizu K, *Kaito C
Evaluation of Staphylococcus aureus virulence factors using a silkworm model.
FEMS Microbiol Lett. 326(2):116-24. (2012)

(24) Miyashita A, Iyoda S, Ishii K, Hamamoto H, Sekimizu K, *Kaito C
Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli O157:H7 is required for killing both insects and mammals.
FEMS Microbiol Lett. 333(1):59-68. (2012)

(25) Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, *Sekimizu K
Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence.
PLoS Pathog. 7(2):e1001267. (2011)

(26) Hanada Y, Sekimizu K, *Kaito C
Silkworm apolipophorin protein inhibits Staphylococcus aureus virulence.
J Biol Chem. 286(45):39360-9. (2011)

(27) Kaito C, Hirano T, Omae Y, *Sekimizu K
Digestion of extracellular DNA is required for giant colony formation of Staphylococcus aureus.
Microbial Pathogenesis 51(3):142-8. (2011)

(28) Ueda T, Kaito C, Omae Y, *Sekimizu K
Sugar-responsive gene expression and the agr system are required for colony spreading in Staphylococcus aureus.
Microbial Pathogenesis 51(3):178-85. (2011)

(29) Kaito C, Usui K, Kyuma T, *Sekimizu K
Isolation of mammalian pathogenic bacteria using silkworms.
Drug Discoveries and Therapeutics 5(2):66-70. (2011)

(30) Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, *Wilson IA
Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.
Structure 18:537-47. (2010)

(31) Ikuo M, Kaito C, *Sekimizu K
The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene.
Microbial Pathogenesis 49(1-2):1-7. (2010)

(32) Usui K, Miyazaki S, Kaito C, *Sekimizu K
Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity.
Microbial Pathogenesis 46:59-62. (2009)

(33) Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, *Sekimizu K
A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence in Staphylococcus aureus.
PLoS ONE 3:e3921. (2008)

(34) Nagata M, Kaito C, *Sekimizu K
Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus.
J Biol Chem. 283:2176-84. (2008)

(35) Kaito C, *Sekimizu K
Colony Spreading in Staphylococcus aureus.
J Bacteriol. 189, 2553-7. (2007)

(36) Matsumoto Y, Kaito C, Morishita D, Kurokawa K, *Sekimizu K
Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene.
Infect Immun. 75, 1964-72. (2007)

(37) *Kurokawa K, Kaito C, Sekimizu K
Two-Component Signaling in Virulence of S. aureus: Silkworm Larvae-Pathogenic Agents Infection Model for Virulence.
Methods Enzymol. 422:233-44. (2007)

(38) Kaito C, Morishita D, Matsumoto Y, Kurokawa K, *Sekimizu K
Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus.
Mol Microbiol. 62, 1601-1617. (2006)

(39) Hossain MS, Hamamoto H, Matsumoto Y, Razanajatovo IM, Larranaga J, Kaito C, Kasuga H, *Sekimizu K
Use of silkworm larvae to study pathogenic bacterial toxins.
J Biochem. 140, 439-44. (2006)

(40) Eguchi Y, Ueno S, Kaito C, Sekimizu K, *Shiokawa K
Cleavage and survival of Xenopus embryos exposed to 8 T static magnetic fields in a rotating clinostat.
Bioelectromagnetics 27, 307-13. (2006)

(41) Kaito C, *Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K
Silkworm-pathogenic bacteria infection model for identification of novel virulence genes.
Mol Microbiol. 56, 934-44 (2005)

(42) Kawamura N, *Kurokawa K, Ito T, Hamamoto H, Koyama H, Kaito C, Sekimizu K
Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation.
Genes Cells. 10, 477-87 (2005)

(43) *Shiokawa K, Takayama E, Higo T, Kuroyanagi S, Kaito C, Hara H, Kajitani M, Sekimizu K, Tadakuma T, Miura K, Igarashi K, Yaoita Y
Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae.
Biochem Biophys Res Commun. 336, 682-91. (2005)

(44) Hamamoto H, Kurokawa K, Kaito C, Kamura K, Manitra Razanajatovo I, Kusuhara H, Santa T, *Sekimizu K
Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms.
Antimicrob Agents Chemother. 48, 774-9 (2004)

(45) Kai M, Kaito C, Fukamachi H, Higo T, Takayama E, Hara H, Ohya Y, Igarashi K, *Shiokawa K
Overexpression of S-adenosylmethionine decarboxylase (SAMDC) in Xenopus embryos activates maternal program of apoptosis as a “fail-safe” mechanism of early embryogenesis.
Cell Res. 13, 147-58 (2003)

(46) Ichihashi N, Kurokawa K, Matsuo M, Kaito C, *Sekimizu K
Inhibitory effects of basic or neutral phospholipid on acidic phospholipid-mediated dissociation of adenine nucleotide bound to DnaA protein, the initiator of chromosomal DNA replication.
J Biol Chem. 278, 28778-86 (2003)

(47) Matsuo M, Kurokawa K, Nishida S, Li Y, Takimura H, Kaito C, Fukuhara N, Maki H, Miura K, Murakami K, *Sekimizu K
Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus.
FEMS Microbiol Lett. 222, 107-13 (2003)

(48) Kaito C, Akimitsu N, Watanabe H, *Sekimizu K
Silkworm larvae as an animal model of bacterial infection pathogenic to humans.
Microbial Pathogenesis 32, 183-90 (2002)

(49) Kaito C, Kurokawa K, Hossain MS, Akimitsu N, *Sekimizu K
Isolation and characterization of temperature-sensitive mutants of the Staphylococcus aureus dnaC gene.
FEMS Microbiol Lett. 210, 157-64 (2002)

(50) Inoue R, Kaito C, Tanabe M, Kamura K, Akimitsu N, *Sekimizu K
Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus.
Mol Genet Genomics. 266, 564-71 (2001)

(51) Kaito C, Kai M, Higo T, Takayama E, Fukamachi H, Sekimizu K, *Shiokawa K
Activation of the maternally preset program of apoptosis by microinjection of 5-aza-2′-deoxycytidine and 5-methyl-2′-deoxycytidine-5′-triphosphate in Xenopus laevis embryos.
Dev Growth Differ. 43, 383-90 (2001)

(52) Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, Inoue R, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, *Hiramatsu K
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Lancet 357, 1225-40 (2001)

(53) Kai M, Higo T, Yokoska J, Kaito C, Kajita E, Fukamachi H, Takayama E, Igarashi K, *Shiokawa K
Overexpression of S-adenosylmethionine decarboxylase (SAMDC) activates the maternal program of apoptosis shortly after MBT in Xenopus embryos.
Int J Dev Biol. 44, 507-10 (2000)