S. Maehara, S. Nishiyama, M. Maruyama, K. Higaki. Analysis of discrepancy in SNEDDS performance for a "brick dust" mebendazole between in-vitro and in-vivo estimation. European Journal of Pharmaceutics and Biopharmaceutics, 218, 114911 (2026).

S. Nishiyama, Y. Takemoto, K. Yamanouchi, K. Kondo, S. Kawatsu, M. Maruyama, K. Higaki. Dynamic changes in the distribution equilibrium of drugs in nanoemulsions associated with drug absorption facilitate the absorption improvement for poorly water-soluble drugs by SNEDDS. Int. J. Pharm., 674, 125458 (2025)

M. Maruyama, R. Torii, H. Matsui, H. Hayashi, K. Ogawara, K. Higaki. Repeated sequential administration of pegylated emulsion of SU5416 and liposomal paclitaxel enhances anti-tumor effect in 4T1 breast cancer-bearing mice. Eur. J. Pharm. Biopharm., 209, 114663 (2025)

M. Maruyama, T. Ueda, Y. Ienaka, H. Tojo, K. Hyodo, K. Ogawara, K. Higaki. EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to doxorubicin-PEG-liposomes in mice bearing doxorubicin-resistant B16-BL6 tumors. J. Drug Deliv. Sci. Technol., 106, 106690 (2025)

S. Aikawa, H. Tanaka, H. Ueda, M. Maruyama, K. Higaki. Specific intermolecular interaction with sodium glycocholate generates the co-amorphous system showing higher physical stability and aqueous solubility of Y5 receptor antagonist of neuropeptide Y, a brick dust molecule. Eur J Pharm Biopharm., 202, 114395 (2024)

M. Maruyama, H. Matsui, H. Nakamura, R. Torii, Y. Takasugi, K. Ogawara, K. Higaki. Vascular normalization with pegylated emulsion of SU5416 enhances anti-tumor effect of liposomal paclitaxel in 4T1 breast cancer-bearing mice: Analysis of intratumoral vessels and microenvironment. J. Drug Deliv. Sci. Technol., 96, 105647 (2024)

T. Inoue, S. Maehara, M. Maruyama, K. Higaki. Combination of co-amorphization with SNEDDS outperforms Ofev® in the oral absorption of nintedanib. Int J Pharm., 657, 124197 (2024)

H. Mukai, M. Takanashi, K. Ogawara, M. Maruyama, K. Higaki. Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers. J Pharm Sci., 113 (5), 1209-1219 (2024).

T. Shehata, Y. Kono, K. Higaki, T. Kimura and K. Ogawara:　In vivo distribution characteristics and anti-tumor effect of doxorubicin encapsulated in PEG-modified niosomes in solid tumor-bearing mice. J. Drug Deliv. Sci. and Technol., 80, 104122 (2023).

Y. Takamura, S. Kikuzawa, M. Fujihara, Y. Sunatsuki, H. Ota, K. Higaki and H. Kakuta: Characterization and interconversion of two crystal forms of Net-3IB, a retinoid X receptor agonist. Chem. Pharm. Bull., 71 (4), 282-288 (2023).

M. Gomi, N. Mizutani, R. Senoo, N. Matsubara, A. Watanabe, M. Maruyama, G. Kimura, K. Higaki. Development of Sustained Release System Based on High Water-Absorbable Gel Formation Using Croscarmellose Sodium, Alkaline Excipients and HPMC (ACSH SR System); Novel Application of Croscarmellose Sodium as a Gel Former. Pharm Res., 40, 3073-3086 (2023)

M. Maruyama, M. Yoshikata, M. Sakaguchi, S. Wakushima, K. Higaki. Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs. Int. J. Pharm., 633, 122617 (2023)

K. Yamanouchi, T. Ishimaru, T. Kakuno, Y. Takemoto, S. Kawatsu, K. Kondo, M. Maruyama, K. Higaki. Improvement and characterization of oral absorption behavior of clofazimine by SNEDDS: Quantitative evaluation of extensive lymphatic transport. Eur. J. Pharm. Biopharm., 187, 141-155 (2023).

S. Aikawa, H. Tanaka, H. Ueda, M. Maruyama, K. Higaki. Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature. Pharmaceutics., 15, 84 (2023).

S. Nakashima, T. Iwamoto, M. Takanashi, K. Ogawara, M. Maruyama, K. Higaki: Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats: Pharm. Res., 39, 2163-2178 (2022).

M. Onishi, K. Tagawa, M. Jiko, K. Koike, M. Maruyama, H. Hashizume, K. Imagaki, K. Higaki: Efficient Evaluation of In Vivo Performance in Human for Generic Formulation by Novel Dissolution-Absorption Prediction (DAP) Workflow: Pharm. Res., 39, 2203-2216 (2022).

M. Maruyama, Y. Nishida, H. Tanaka, T. Minami, K.I. Ogawara, M. Miyake, Y. Takamura, H. Kakuta, K. Higaki: Analysis of absorption-enhancing mechanisms for combinatorial use of spermine with sodium taurocholate in Caco-2 cells. Eur. J. Pharm. Biopharm., 180, 332-343 (2022).

Y. Kono, A. Fushimi, Y. Yoshizawa, K. Higaki and K. Ogawara: Effects of particle size and release property of paclitaxel-loaded nanoparticles on their peritoneal retention and therapeutic efficacy against mouse malignant ascites: Int. J. Pharm., 623, 121904 (2022).

Y. Sumimoto, S. Okawa, T. Inoue, K. Masuda, M. Maruyama, K. Higaki. Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its counter ion. Eur. J. Pharm. Biopharm.,172, 213-227 (2022)

M. Maruyama, H. Tojo, K. Toi, Y. Ienaka, K. Hyodo, H. Kikuchi, K. Ogawara, and K. Higaki: Effect of Doxorubicin Release Rate From Polyethylene Glycol-Modified Liposome on Anti-tumor Activity in B16-BL6 Tumor-Bearing Mice. J. Pharm. Sci., 111, 293-297, (2022).

T. Minamisakamoto, S. Nishiguchi, K. Hashimoto, K. Ogawara, M. Maruyama, and K. Higaki: Sequential administration of PEG-Span 80 niosome enhances anti-tumor effect of doxorubicin-containing PEG liposome. Eur. J. Pharm. Biopharm., 169, 20-28 (2021).

H. Mukai, M. Takanashi, K. Ogawara, M. Maruyama, and K. Higaki: Possible Regulation of P-glycoprotein Function by Adrenergic Agonists in a Vascular-luminal Perfused Preparation of Small Intestine. J. Pharm. Sci., 110 (12), 3889-3895 (2021).

S. Okawa, Y. Sumimoto, K. Masuda, K. Ogawara, M. Maruyama and K. Higaki: Improvement of lipid solubility and oral bioavailability of a poorly water- and poorly lipid-soluble drug, rebamipide, by utilizing its counter ion and SNEDDS preparation. Eur. J. Pharm. Sci., 159, 105721 (2021).

M. Miyake, T. Minami, M. Maruyama, T. Mukai and K. Higaki: Spermine with sodium taurocholate enhances pulmonary absorption of macromolecules in rats. J. Pharm. Sci., 110 (10), 3464-3470 (2021).

M. Maruyama, Y. Nakano, T. Nishimura, R. Iwata, S. Matsuda, M. Hayashi, Y. Nakai, M. Nonaka and T. Sugimoto: PC3-secreted microprotein is expressed in glioblastoma stem-like cells and human glioma tissues. Biol. Pharm. Bull., 44 (7), 910-919 (2021).

K. Kohara, A. Inoue, Y. Nakano, H. Hirai, T. Kobayashi, M. Maruyama, R. Baba and C. Kawashima: BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System. iScience, 23 (6), 101248 (2020).

R. Iwata, J. Hyoung Lee, M. Hayashi, U. Dianzani, K. Ofune, M. Maruyama, S. Oe, T. Ito, T. Hashiba, K. Yoshimura, M. Nonaka, Y. Nakano, Norian L., I. Nakano and A. Asai: ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma. Neuro. Oncol., 22 (3), 333-344 (2020).

K. Okada, A. Sato, A. Hiramoto, R. Isogawa, Y. Kurosaki, K. Higaki, S-I. Miyoshi, K-S. Chang and H-S. Kim: Pharmacokinetic analysis of new synthetic antimalarial N-251. Trop. Med. Health, 47, 40 (2019).

D. Inoue, A. Tanaka, S. Kimura, A. Kiriyama, H. Katsumi, A. Yamamoto, K. Ogawara, T. Kimura, K. Higaki, R. Yutani, T. Sakane, T. Furubayashi: The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption: Eur. J. Pharm. Sci., 117, 21-26 (2018).

D. Inoue, S. Kimura, A. Kiriyama, H. Katsumi, A. Yamamoto, K. Ogawara, K. Higaki, A. Tanaka, R. Yutani, T. Sakane, T. Furubayashi: Quantitative estimation of the effect of nasal mucociliary function on in vivo absorption of norfloxacin after intranasal administration to rats: Mol. Pharm., 15 (10), 4462-4469 (2018).

The involvement of cancer stem cells in brain metastatic process. R. Iwata, M. Maruyama, K. Ofune, Y. Nakano, S. Oe, M. Hayashi, K. Yoshimura, M. Nonaka and A Asai: Cytometry Res., 28 (1), 13-18 (2018).

R. Iwata, M. Maruyama, T. Ito, Y. Nakano, Y. Kanemura, T. Koike, S. Oe, K. Yoshimura, M. Nonaka, S. Nomura, T. Sugimoto, H. Yamada and A. Asai: Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor. Med. Mol. Morphol., 50 (4), 211-219 (2017).